Title: "Inferring disease related gene-gene interactions: a fuzzy logic based approach"

Abstract: There have been many attempts to infer gene-gene interactions from microarray data based on different approaches such as mutual information, Bayesian networks, and differential equations. The gene-gene interactions identified by such methods reveal important and interesting biological functions, but all of these may not be related to a phenotype, say, a particular cancer. In this talk we shall focus on identification of gene-gene interactions, which are related to a particular disease. Two genes individually may be related to a particular cancer but we are not interested in such pairs. The objective here is to identify pairs of genes whose cooperative behavior make them related to the disease. There have been a few attempts to address this problem based on information theoretic concepts. In this talk first we shall discuss the main philosophy behind such approaches and some associated issues/problems. Then we shall present a very simple fuzzy set theoretic method for inferring gene-gene interactions associated to a particular type of disease/cancer. Our method is based on a set of fuzzy rules. The advantages of this fuzzy approach over the existing ones will be discussed. Finally, we shall demonstrate the effectiveness of our method on a benchmark data set.


Nikhil R. Pal is a Professor in the Electronics and Communication Sciences Unit of the Indian Statistical Institute. He has also served as a Chair Professor at the National Chiao Tung University, Taiwan and as a visiting professor at other universities. He has coauthored, edited/co-edited several books. His current research interest includes bioinformatics, brain science, fuzzy logic, image and pattern analysis, neural networks, and evolutionary computation. He serves on the editorial /advisory board/ steering committee of several journals including the International Journal of Approximate Reasoning, Applied Soft Computing, Neural Information Processing—Letters and Reviews, International Journal of Knowledge-Based Intelligent Engineering Systems, International Journal of Neural Systems, Fuzzy Sets and Systems ,International Journal of Intelligent Computing in Medical Sciences and Image Processing, Fuzzy Information and Engineering : An International Journal, and the IEEE Transactions on Systems Man and Cybernetics—B. He has been serving as the Editor-in-Chief of the IEEE Transactions on Fuzzy Systems since 2005. He has given many plenary/keynote speeches in different premier international conferences in the area of computational intelligence. He was the president of the Asia Pacific Neural Net Assembly. He was the Program Chair of the 4th International Conference on Advances in Pattern recognition and Digital Techniques, December 1999, Calcutta, India and was a co-program chair of 2005 IEEE International Conference on Fuzzy Systems and 2006 IEEE International Conference on Fuzzy Systems. He was the General Chair of 2002 AFSS International Conference on Fuzzy Systems, Calcutta, 2002 and the 11th International Conference on Neural Information Processing, ICONIP 2004. He is a Fellow of the National Academy of Sciences, India, a Fellow of the Indian National Academy of Engineering, a Fellow of the International Fuzzy Systems Association (IFSA), and a Fellow of the IEEE, USA.


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